Estradiol Patch

Delivers bioidentical estradiol continuously through the skin over a 7-day wear period, bypassing the liver on first pass. A good starting point for members new to hormone therapy or especially sensitive to hormones.

• Steady relief from hot flashes and night sweats
• Good starting dose for HRT-sensitive members
• Dose adjustable based on response

• Strength: 0.025mg, 0.05mg, or 0.1mg per 24hr, depending on the option you choose
• Supply: 4 patches (1-month) or 12 patches (3-month)
• Route: Transdermal patch, lower abdomen or upper buttock
• Frequency: Replace weekly
• Approval: FDA-approved

Apply one patch to clean, dry, intact skin on the lower abdomen or upper buttock and replace it once weekly.

Rotate application sites, and avoid applying the patch to the breasts, waistline, or irritated skin.

• Breast tenderness, headache, bloating, or nausea
• Mild irritation where the patch is applied

• History of breast, endometrial, or other estrogen-sensitive cancer
• Undiagnosed abnormal vaginal bleeding
• Active or prior blood clots, stroke, or heart attack
• Liver disease or known thrombophilia
• Pregnancy
• Members with a uterus need a progestin alongside this patch
• Smoking increases blood clot and stroke risk on estrogen therapy

As of late 2025, the FDA is removing the long-standing black box warning from estrogen-only hormone therapy products, based on newer research showing the original 2002 warning overstated risk for most candidates — particularly with lower-dose, transdermal formulations like this one.

The FDA is retaining a boxed warning specifically for endometrial cancer risk in members with a uterus using estrogen without a progestin.

Members should have regular breast exams, pelvic exams, and mammograms while on therapy, and should discuss their personal risk factors with their provider before starting.